![]() ![]() Moreover, Daqin railway transportation within October 1-10 totaled around 1 mio t/day, down 0.3 mio t/day instead of the expected 0.2 mio t/day caused by the maintenance work. Thus, coal shipments from some mining regions dropped to 40% of normal levels. In China, spot prices for 5,500 NAR at the port of Qinhuangdao strengthened to 217 USD/t (+4 USD/t w-o-w), driven by expected supply cuts for the period of the 20th Communist Party of China Congress and new restrictions because of the spread of COVID-19 in Inner Mongolia, resulting in Shaanxi coal province taking preventive measures and tightening controls at the border. Representatives of South Africa’s sectoral ministries joined a labour dispute on October 12 to resolve the issue, as Transnet was proposing a 4-5% wage rise, while unions were demanding a 12-13.5% increase. As of October 11, RBCT reserves stood at about 3.0 mio t (-1.0 mio t w-o-w). Unlike the general cargo and bulk terminals at the ports of Richards Bay and Durban, the Richards Bay Coal Terminal (RBCT) keeps operating as usual, however, coal stocks continue to shrink and could be depleted within the next two weeks, that may push up prices. ![]() On October 12, railway operator Transnet and representatives of the 2 trade unions (UNTU and SATAWU) resumed negotiations, potentially leading to the completion of a 7-day strike, which negatively impacted coal transportation and handling, prompting Transnet to declare force majeure. South African High-CV 6,000 dropped below 235 USD/t due to lower demand from India and Pakistan, boosting the consumption of more competitive Russian and Mozambican coal. ![]() Coal stocks at ARA terminals marginally decreased to 7.7 mio t (-0.10 mio t or -2% w-o-w). At the same time, hydro generation jumped 67% to 1.14 GW, solar generation surged 37% to 6.67 GW, while onshore and offshore wind power output moved up 38% to 4.10 GW and 5% to 13.10 GW respectively. Between October 3-9, coal and gas generation in Germany declined 25% from the previous week to 2.86GW and 4.94GW respectively. Diagnosing the decline in pharmaceutical R&D efficiency. A standard database for drug repositioning. Drug repositioning for Alzheimer’s disease based on systematic “omics” data mining. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Alzheimer’s Dement Transl Res Clin Interv 2017 3: 367– 384. Alzheimer’s disease drug development pipeline: 2017. Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Fabuleux hasards: histoire de la découverte de médicaments. Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. Opportunities for drug repositioning from phenome-wide association studies. Abingdon: Taylor & Francis Group, 2017: 3– 22. Drug Repositioning – Approaches and Applications for Neurotherapeutics. ![]() Scientific commercial value of drug repurposing. Therapeutic drug repurposing: repositioning and rescue. Can you teach old drugs new tricks? Nature 2016 534: 314– 316. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Systematic drug repositioning for a wide range of diseases with integrative analyses of phenotypic and molecular data. On the integration of in silico drug design methods for drug repurposing. Selective optimization of side activities: the SOSA approach. Drug repositioning and repurposing: terminology and definitions in literature. Drug repositioning: identifying and developing new uses for existing drugs. Drug repurposing: progress, challenges and recommendations. Key papers and their related key findings are summarized in Table 2. ![]()
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